David Lyttle

 

I completed my doctorate in Applied Mathematics from the University of Arizona in 2013, under the joint supervision of Dr. Jean-Marc Fellous and Dr. Kevin Lin. My graduate work focused primarily on topics in computational neuroscience, such as the metric space analysis of spike train data [4], and computational models of place cell and grid cell networks [3] (and also a bit of theoretical population genetics [5]). After graduating, I was awarded an NSF Postdoctoral Fellowship in Biology to study the neural and biomechanical mechanisms of rhythmic motor pattern generation [1,2], under the supervision of Dr. Hillel Chiel and Dr. Peter Thomas at Case Western Reserve University.

I joined the Neural Circuits and Memory Lab as a postdoc in January of 2016. My current research focuses on how interactions between different hippocampal subfields (specifically CA3 and CA1) contribute to the complex patterns of activity underlying episodic memory formation (e.g. spike sequences, sharp-wave ripples, and theta and gamma oscillations).  My research uses a mix of experimental and theoretical techniques, including high-density in vivo electrophysiological recordings, optogenetics,  and computational modeling.

Publications

[1 ] Lyttle, D., Gill, J., Shaw, K., Thomas, P., and Chiel, H. Robustness, flexibility, and sensitivity in a multifunctional motor control model. Submitted, (2016).

[2] Shaw, K., Lyttle, D., Gill, J., Cullins, M., McManus, J., Lu, H., Thomas, P., and Chiel, H. The significance of dynamical architecture for adaptive responses to mechanical loads during rhythmic behavior. Journal of Computational Neuroscience, (2015).

[3] Lyttle, D., Lin, KK., Gereke, B and Fellous, J-M., Spatial scale and place field stability in a modular grid-to-place cell model of the dorsoventral axis of the hippocampus. Hippocampus, (2013).

[4] Lyttle, D., and Fellous, J-M., A new similarity measure for spike trains: sensitivity to bursts and periods of inhibition. Journal of Neuroscience Methods, (2011).

[5] Masel, J., and Lyttle, D. The consequences of rare sexual reproduction by means of selfing in an otherwise clonally reproducing species. Theoretical Population Biology, (2011).